Fig. 9

Transmission electron microscopy of PH established in control groups and PH.Anc.80AC treated rats 8 weeks post-PH development). A Sham. Normal, flat endothelial cells in the alveolo-capillary membrane separated from smooth muscle cells (white arrows) by thick basement membrane (yellow arrows). B PH.Anc80.Null. Intimal lesion displaying invagination of endothelial cells in the intima (white arrows). Swollen endothelium and thickened interstitium. Many collagens elastic fibers (yellow arrow). C PH.Saline Alveolar edema with fibrin in alveoli’s (white arrow). Presenting many inflammatory cells in interstitium. Degeneration of red and white blood cells with damaged the basement membrane (yellow arrow). D PH.Anc80.AC Endothelial layer denser and preserved (yellow arrow). Decreased number of inflammatory cells in the interstitium (white arrow), no alveolar edema. Bar scale: 10 μm, magnification: 2.500