Fig. 10

Changes in pro-inflammatory and anti-inflammatory cytokines expression at 8 weeks post-PH development. Among 23 cytokines investigated, a significant decrease of TNFα, INFγ, and interleukins 1, 6, 10, 12 were observed in Anc80.AC treated animals compared to untreated groups. The dendrogram shows the clustering of cytokines. The vertical line is name of cytokine. The horizontal line is group of the animals. The colors represent expression of IL, interleukin; EPO, erythropoietin; M CSF, macrophage colony-stimulating factor; MCP1 CCL2, monocyte chemoattractant protein; TNFα, tumor necrosis factor; G CSF, granulocyte colony-stimulating factor; IFNγ, interferon gamma; MIP3 CCL20, macrophage inflammatory protein; GRO KC CXCL 1, chemokine ligand; GLP 1, glucagon-like peptide; GM CSF, granulocyte–macrophage colony-stimulating factor