Table 4 Univariate and multivariate binary logistic regression analyses to identify factors associated with indeterminate results due to low Mitogen IFN-γ levels in the IGRA (QFT-GIT)

Age groups

 ≤ 14

7.52

6.10–9.27

< 0.0001

5.28

2.82–9.88

< 0.0001

 15–47

Reference

Reference

 48–63

2.25

1.97–2.57

< 0.0001

1.54

1.07–2.23

0.022

 ≥ 64

7.33

6.45–8.34

< 0.0001

2.26

1.48–3.45

0.0002

Sex (male/female)

1.24

0.96–1.61

0.094

Smoking

 Non-smoker

Reference

Reference

 Smoker

1.56

1.09–2.22

0.015

1.45

0.95–2.20

0.085

 Ex-smoker

1.77

1.19–2.63

0.005

1.36

0.84–2.22

0.206

Active TB

1.73

1.07–2.79

0.024

1.26

0.72–2.21

0.421

History of TB

1.63

0.92–2.88

0.094

NTM infection

2.00

0.73–5.51

0.181

Hematologic malignancy

8.21

4.98–13.52

< 0.0001

1.71

0.92–3.16

0.089

Renal insufficiency

3.80

2.16–6.68

< 0.0001

1.02

0.51–2.07

0.948

Solid malignancy

3.91

2.22–6.88

< 0.0001

2.05

1.04–4.01

0.038

Diabetes mellitus

2.95

2.05–4.25

< 0.0001

1.03

0.65–1.63

0.911

Chronic liver disease

6.07

2.54–14.51

< 0.0001

1.92

0.72–5.11

0.192

HIV infection

1.79

0.83–3.87

0.137

Cardiac disease

2.14

1.45–3.16

0.0001

0.98

0.61–1.57

0.938

COPD

3.20

1.71-6.00

0.0003

1.10

0.52–2.33

0.809

Autoimmune disease

4.59

3.53–5.96

< 0.0001

4.39

3.05–6.32

< 0.0001

Corticosteroids

9.36

7.22–12.13

< 0.0001

4.16

2.99–5.79

< 0.0001

Immunosuppressant

3.58

2.70–4.76

< 0.0001

1.18

0.80–1.74

0.412

Acute Infection

7.16

5.09–10.08

< 0.0001

2.08

1.30–3.31

0.002

Lymphopenia

11.28

8.57–14.85

< 0.0001

3.09

2.14–4.47

< 0.0001

Neutropenia

0.68

0.47–0.99

0.043

0.85

0.54–1.33

0.469

CRP

1.10

1.08–1.12

< 0.0001

1.07

1.05–1.10

< 0.0001

Hypoalbuminemia

15.53

11.87–20.32

< 0.0001

3.06

2.11–4.42

< 0.0001