Table 3 Univariate and multivariate binary logistic regression analyses to identify factors associated with high Nil IFN-γ levels in the IGRA (QFT-GIT)

Age, years

 ≤ 14

1.23

0.91–1.68

0.183

1.23

0.90–1.68

0.200

 15–47

Reference

Reference

 48–63

1.07

0.96–1.19

0.210

1.08

0.96–1.20

0.200

 ≥ 64

1.18

1.00-1.39

0.049

1.16

0.97–1.37

0.105

Sex (male/female)

0.97

0.89–1.05

0.432

Smoking status

 Non-smoker

Reference

 Smoker

0.88

0.75–1.05

0.147

 Ex-smoker

0.92

0.76–1.13

0.439

Active TB

2.87

2.31–3.57

< 0.0001

2.77

2.16–3.37

< 0.0001

History of TB

1.43

1.14–1.81

0.002

1.28

1.01–1.63

0.044

Recent contact with TB

0.75

0.58–0.97

0.031

0.83

0.61–1.13

0.238

NTM infection

1.36

0.86–2.15

0.194

Hematologic malignancy

1.29

0.86–1.94

0.212

Renal insufficiency

0.93

0.67–1.30

0.672

Solid malignancy

0.62

0.44–0.88

0.008

0.53

0.37–0.76

0.001

Diabetes mellitus

0.96

0.80–1.15

0.679

Chronic liver disease

0.83

0.43–1.59

0.573

HIV infection

1.11

0.80–1.54

0.548

Cardiac disease

1.05

0.88–1.24

0.614

COPD

1.06

0.75–1.49

0.754

Autoimmune disease

0.71

0.63–0.81

< 0.0001

0.76

0.65–0.88

0.0003

Corticosteroids

0.89

0.77–1.03

0.106

Immunosuppressant

0.75

0.65–0.86

< 0.0001

0.90

0.77–1.07

0.226

Acute infection

0.89

0.70–1.13

0.329

Lymphopenia

1.17

1.11–1.23

0.051

1.12

0.96–1.30

0.160

Neutropenia

1.10

0.94–1.29

0.224

1.11

0.95–1.30

0.185

CRP

1.01

0.99–1.03

0.245

Hypoalbuminemia

1.19

0.98–1.44

0.081