Table 2 Diagnostic performance of Nil, TBAg, and TBAg–Nil IFN-γ levels for differentiation of active TB cases from those in other groups
From: Enhancing the interferon-γ release assay through omission of nil and mitogen values
AUC | 95% CI | Cut-off | Sensitivity | Specificity | |
|---|---|---|---|---|---|
All active-TB cases (n = 412) vs. All non-TB groups (n = 8,715) | |||||
Nil | 0.697 | 0.687 — 0.706 | 0.19 IU/mL | 49.0 | 80.8 |
TBAg | 0.918 | 0.912 — 0.923 | 0.55 IU/mL | 93.2 | 81.6 |
TBAg − Nil | 0.912 | 0.906 — 0.917 | 0.38 IU/mL | 91.3 | 83.1 |
All active-TB cases (n = 412) vs. IGRA-positive non-TB group (n = 1,513) | |||||
Nil | 0.623 | 0.601 — 0.645 | 0.19 IU/mL | 49.0 | 71.2 |
TBAg | 0.613 | 0.591 — 0.635 | 3.38 IU/mL | 60.9 | 59.3 |
TBAg − Nil | 0.597 | 0.574 — 0.619 | 3.03 IU/mL | 60.0 | 58.6 |
Bacteriologically diagnosed active-TB cases (n = 297) vs. All non-TB groups (n = 8,715) | |||||
Nil | 0.759 | 0.751 — 0.768 | 0.20 IU/mL | 58.2 | 82.3 |
TBAg | 0.921 | 0.915 — 0.927 | 0.56 IU/ml | 92.9 | 81.8 |
TBAg − Nil | 0.912 | 0.907 — 0.918 | 0.41 IU/mL | 90.6 | 83.6 |
Bacteriologically diagnosed active-TB cases (n = 297) vs. IGRA-positive Non-TB group (n = 1,513) | |||||
Nil | 0.689 | 0.667 — 0.710 | 0.19 IU/mL | 59.6 | 71.2 |
TBAg | 0.624 | 0.602 — 0.647 | 3.95 IU/mL | 59.6 | 62.7 |
TBAg − Nil | 0.601 | 0.578 — 0.624 | 2.47 IU/mL | 65.3 | 54.1 |