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Table 3 Association with renal dysfunction (serum creatinine level) among 353 African American sepsis patients

From: Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure

Marker

Chr. 2 Position

(hg19)

Function

Alleles

MAF

Beta*

(95% CI)

Pcrude

Padj**

rs4952085

31,570,689

intron 27

 A/G

0.226

0.493

(0.215–0.771)

0.015

0.0006

rs1884725

31,571,786

coding-synonymous (exon 27)

G/A

0.225

0.504

(0.224–0.784)

0.015

0.0005

  1. *Beta: regression coefficient, with each additional copy of the minor risk alleles (the ‘G’ or ‘A’ allele for rs4952085 or rs1884725, respectively), the average increase in serum creatinine concentration was 0.5 mg/dL (normal range: 0.5–1.2 mg/dL)
  2. **Linear regression generated P values adjusted for demographic characteristics (age, sex and African ancestry) and APACHE II scores
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Respiratory Research

ISSN: 1465-993X

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