Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure

Respiratory Research

Table 1 Demographics and clinical characteristics of sepsis patients with and without ARDS in CELEG population

	Total			Sepsis (w/o ARDS)			Sepsis (w/ ARDS)
	European American	African American	P	European American	African American	P	European American	African American	P
N	621	353		324	195		297	158
Sex (M/F)	352/269	176/177	0.05	175/149	89/106	0.07	177/120	87/71	0.37
Age (yrs)	60.0 ± 16.7	54.8 ± 17.3	< 0.0001	62.6 ± 15.8	58.9 ± 16.2	0.01	57.3 ± 17.2	49.7 ± 17.2	< 0.0001
APACHE II	25.7 ± 8.0	25.3 ± 8.1	0.38	23.9 ± 8.1	23.8 ± 7.4	0.87	27.8 ± 7.5	27.1 ± 8.6	0.42
Mortality (%)	32.53	36.54	0.21	26.23	26.15	1.0	39.39	49.37	0.05
Insult (%) Lung Blood Abdomen UTI Other	302 (49.6) 70 (11.5) 88 (14.4) 72 (11.8) 77 (12.6)	150 (44) 60 (17.6) 38 (11.1) 39 (11.4) 54 (15.8)	0.03	105 (33.1) 42 (13.2) 55 (17.4) 61 (19.2) 54 (17)	62 (32.8) 36 (19) 23 (12.2) 29 (15.3) 39 (20.6)	0.16	197 (67.5) 28 (9.6) 33 (11.3) 11 (3.8) 23 (7.9)	88 (57.9) 24 (15.8) 15 (9.9) 10 (6.6) 15 (9.9)	0.13
Comorbidities (%)
HIV	4.52	17.85	< 0.0001	3.10	15.90	< 0.0001	6.06	20.25	< 0.0001
AIDS	2.58	11.90	< 0.0001	2.17	8.72	< 0.0001	3.03	15.82	< 0.0001
RF	45.48	44.76	0.84	43.65	44.62	0.85	47.47	44.94	0.62
CLD	12.90	4.82	< 0.0001	10.22	4.10	0.01	15.82	5.70	0.002
Diabetes	26.45	35.41	0.004	30.65	43.08	0.01	21.89	25.95	0.35
Alcoholism	16.13	18.98	0.29	11.15	16.41	0.11	21.55	22.15	0.91
COPD	21.29	10.76	< 0.0001	21.67	10.77	0.002	20.88	10.76	0.006
Cancer	19.68	12.75	0.01	23.22	10.77	< 0.0001	15.82	15.19	0.89
CHF	11.29	11.08	1.0	11.76	11.79	1.0	10.77	10.19	1.0
Anemia	18.55	17.00	0.60	19.50	21.03	0.73	17.51	12.03	0.14

Total cohort = 974 subjects, definition of abbreviations: APACHE II = Acute Physiology and Chronic Health Evaluation; CLD = Chronic Liver Disease; RF = Renal Failure; UTI = Urinary Tract Infection; CNS = Central nervous system; Age and APACHE II data expressed as mean ± SD; Mortality is measured up to 60 days
Two group comparisons were carried out using either a two-tailed Student’s t-test for age and APACHE II score or Fisher’s exact test for categorical variables (sex and survival). Chi-square test was applied for clinical variable insult. P values under the Total, Sepsis and ARDS heading refer to differences between races. Significance level was set at P ≤ 0.05

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