Fig. 1
From: Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure
Summary distributions of -log10 (P value) for association between XDH SNPs and risk, renal dysfunction among African American patients with sepsis. Top panel: A locus-zoom plot of the top loci from single marker association analysis for risk of sepsis and renal dysfunction. The Y axis indicates the negative log of the P value with recombination rates estimated from the 1000 Genomes Project CEU data, and the X axis indicates the genomic position for SNPs genotyped in XDH, 3’ to 5’ direction (on reverse strand). The circle and square in black represent signals for risk of sepsis and serum creatinine levels, respectively; the two SNPs associated with creatinine concentration are distinguished in purple. SNP rs4952085 is used as index SNP, and the r2 values of remaining SNPs are indicated by color. The grey horizontal line represents the significance level of P = 0.05. Middle panel illustrates the XDH gene structure on chromosome 2 and relative positions of 28 SNPs in the gene. Bottom panel shows conserved domains (Fer2_2 S, FAD_binding_4 supe, CO_deh_flav, Ald_Xan_ dh_c and Ald_Xan_dh_C2 superfamily) on human xanthine dehydrogenase/oxidase (NP_000370)