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Fig. 9 | Respiratory Research

Fig. 9

From: CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension

Fig. 9

Integrated model depicting circItgb5 promoting pulmonary artery remodeling. The expression of circItgb5 was abnormally upregulated by PDGF-BB stimulation. Abnormally elevated circItgb5 levels can activate two pathways. On the one hand, circItgb5 sponges miR-96-5p to inhibit its activity. Decreased expression of miR-96-5p upregulates mTOR level, which promotes synthetic phenotype of PASMCs. On the other hand, circItgb5 enhances Uba1 protein expression, following Ube2n and Mdm2 activation. Mdm2 decreased ACE2 expression. Taken together, circItgb5 promotes synthetic phenotype of PASMCs, eventually resulting in pulmonary artery remodeling

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Respiratory Research

ISSN: 1465-993X

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