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Fig. 3 | Respiratory Research

Fig. 3

From: CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension

Fig. 3

Silencing of circItgb5 in vivo decreases ECM deposition in small pulmonary arteries and the right ventricle. A Masson staining of small pulmonary arteries (original magnification, × 200; scale bar = 50 µm) and hearts (original magnification, × 1; scale bar = 5 mm) after knockdown of circItgb5 in vivo. B CircItgb5 expression in the heart of rats. n = 6. *0.01 ≤ P ≤ 0.05 versus control, #0.01 ≤ P ≤ 0.05 versus (Lsh-NC + MCT). C Protein expression of COL1A1 and SM22α in pulmonary arteries was detected by western blotting. **0.001 ≤ P ≤ 0.009 versus control, #0.01 ≤ P ≤ 0.05 versus (Lsh-NC + MCT), ##0.001 ≤ P ≤ 0.009 versus (Lsh-NC + MCT). The data are presented as means ± SD (n = 3 biological replicates)

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Respiratory Research

ISSN: 1465-993X

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