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Fig. 10 | Respiratory Research

Fig. 10

From: Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections

Fig. 10

Pleiotropic effects of VD in transcriptome. A, B Gene set enrichment analysis (GSEA) of transcriptional modulation of H1N1 to airway organoids (NDH_NDC) and of VD treatment in counteracting H1N1 infection (VDH_NDH). C Ingenuity Canonical Pathway Analysis (ICPA) in IPA. Both GSEA And ICPA indicated the importance of TGF-β signaling and EMT. D Examination of mRNA levels of typical EMT-related genes Vimentin, Fibronectin, α-smooth muscle actin (αSMA), MMP2 and TGF-β. E. Upstream regulator analysis in IPA predicted the decreasing TGF-β under VD treatment led to the regulation of other relative genes. Network analysis of VD-modulated DEGs under H1N1 infection clustered in the development, morphogenesis, and organization of epithelial cells. Color in green represents ND control and red for 100 nM VD treatment. F Heatmap of top DEGs colored according to their expression values

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Respiratory Research

ISSN: 1465-993X

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