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Table 3 Association of MMP-3 and APACHE III with mortality by multivariate regression

From: Plasma matrix metalloproteinase-3 predicts mortality in acute respiratory distress syndrome: a biomarker analysis of a randomized controlled trial

 

Univariate

Multivariate

 

OR (95% CI)

P-value

OR (95% CI)

P-value

Day 0 MMP-3 concentration

1.022 (0.983–1.052)

0.28

1.001 (0.98–1.02)

0.89

Day 3 MMP-3 concentration

1.030 (1.008–1.052)

0.007

1.024 (1.004–1.045)

0.026

Day 0 to 3 MMP-3 change

1.005 (0.991–1.019)

0.46

0.999 (0.981–1.017)

0.89

APACHE III

1.032 (1.013–1.051)

< 0.001

1.028 (1.008–1.048)

0.005

  1. MMP-3 variables were all individually tested in logistic regression with APACHE III score as covariates. Model variables that were iteratively removed stepwise included vasopressor use within the 24 h before randomization, PaO2/FiO2 at randomization, sex, and body mass index
  2. APACHE III: Acute Physiology and Chronic Health Evaluation III; MMP-3: matrix metalloproteinase-3
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Respiratory Research

ISSN: 1465-993X

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