Table 2 Relationship between recessive genotype for SNP rs6742078 and respiratory health outcomes. Estimates represent the change in the parameter of interest for the homozygosity for SNP rs6742078 vs. 0 or 1 alleles
Non-Hispanic White | African American | |||
|---|---|---|---|---|
Estimate | 95% Confidence Interval | Estimate | 95% Confidence Interval | |
Mortality - Odds Ratio | 1.042 | 0.703 to 1.510 | 0.801 | 0.391 to 1.513 |
Mortality - Hazard Ratio | 1.050 | 0.840 to 1.313 | 0.848 | 0.563 to 1.279 |
FEV1 at baseline | -0.040 | -0.101 to 0.022 | -0.047 | -0.119 to 0.025 |
FVC at baseline | -0.015 | -0.076 to 0.047 | -0.080 | -0.155 to -0.004 |
FEV1/FVC at baseline | -0.011 | -0.024 to 0.001 | 0.003 | -0.011 to 0.017 |
Change in FEV1, mL/yr | -1.650 | -7.221 to 3.921 | -0.939 | -8.769 to 6.890 |
Change in FVC, mL/yr | -1.335 | -9.733 to 7.062 | 0.515 | -10.117 to 11.146 |
Change in Emphysema, % per yr | -0.021 | -0.104 to 0.062 | -0.005 | -0.087 to 0.076 |
Change in Gas Trapping, % per yr | -0.120 | -0.309 to 0.069 | -0.181 | -0.481 to 0.120 |
Change in Wall Area, mm per yr | 0.011 | -0.083 to 0.105 | 0.076 | -0.100 to 0.252 |
Change in Pi10 mm per yr | 0.002 | -0.005 to 0.009 | 0.006 | -0.007 to 0.018 |
Change in AWT mm per yr | 0.000 | -0.002 to 0.002 | 0.002 | -0.002 -to 0.006 |
Change in Walking Distance, ft/yr | -20.20 | -55.75 to 15.34 | -10.05 | -66.56 to 46.47 |
5-Yr Change in MMRC, Odds Ratio | 1.036 | 0.821 to 1.298 | 1.327 | 0.986 to 1.774 |
5-Yr Change in Total SGRQ | -0.581 | -1.988 to 0.030 | 1.706 | -0.974 to 4.387 |