Table 1 Baseline characteristics by bilirubin SNP rs6742078 alleles. Results are reported as mean (standard deviation) unless otherwise noted
Genotype | Non-Hispanic White | African American | ||||
|---|---|---|---|---|---|---|
0ā1 copies of rs6742078 | 2 copies of rs6742078 | Total | 0ā1 copies of rs6742078 | 2 copies of rs6742078 | Total | |
nā=ā5572 | nā=ā656 | nā=ā6228 | nā=ā2096 | nā=ā403 | nā=ā2499 | |
Age, years | 62.52 (8.71) | 62.33 (8.52) | 62.50 (8.69) | 55.26 (7.54) | 54.32 (6.92) | 55.11 (7.45) |
Female, n (%) | 2696 (48.4) | 331 (50.5) | 3027 (48.6) | 1013 (48.3) | 184 (45.7) | 1197 (47.9) |
BMI, kg/m2 | 28.82 (6.07) | 28.46 (5.84) | 28.79 (6.04) | 29.44 (6.90) | 29.48 (6.91) | 29.45 (6.90) |
Smoking History | Ā | Ā | ||||
Current smoker, n (%) | 2031 (36.5) | 237 (36.1) | 2268 (36.4) | 1621 (77.3) | 315 (78.2) | 1936 (77.5) |
Pack-years | 47.11 (25.96) | 46.57 (24.71) | 47.05 (25.83) | 38.17 (21.35) | 38.24 (20.85) | 38.18 (21.27) |
Spirometry [1] | Ā | Ā | ||||
FEV1/FVC ratio | 0.64 (0.16) | 0.64 (0.17) | 0.64 (0.17) | 0.71 (0.14) | 0.72 (0.14) | 0.71 (0.14) |
FEV1% predicted | 73.68 (25.60) | 73.53 (26.56) | 73.67 (25.70) | 80.97 (24.38) | 79.89 (23.64) | 80.80 (24.26) |
FVC % predicted | 85.89 (17.85) | 86.19 (17.95) | 85.92 (17.86) | 88.90 (18.96) | 86.54 (17.92) | 88.52 (18.82) |
Normal spirometry, n (%) | 2112 (38.0) | 259 (39.7) | 2371 (38.2) | 1084 (52.2) | 207 (52.4) | 1291 (52.2) |
GOLD Stage 1ā2, n (%) | 1699 (30.6) | 193 (29.6) | 1892 (30.5) | 418 (20.1) | 75 (19.0) | 493 (19.9) |
GOLD Stage 3ā4, n (%) | 1144 (20.6) | 136 (20.8) | 1280 (20.6) | 241 (11.6) | 50 (12.7) | 291 (11.8) |
PRISm, n (%) | 601 (10.8) | 65 (10.0) | 666 (10.7) | 334 (16.1) | 63 (15.9) | 397 (16.1) |
Quantitative CT Chest Measurements | Ā | Ā | ||||
AWT-Pi10, mm | 2.33 (0.61) | 2.31 (0.60) | 2.33 (0.60) | 2.37 (0.61) | 2.36 (0.62) | 2.37 (0.61) |
Airway wall area, % | 50.81 (8.35) | 50.54 (8.34) | 50.78 (8.35) | 50.99 (8.74) | 51.05 (8.78) | 51.00 (8.74) |
Emphysema, % | 7.55 (10.40) | 7.96 (10.51) | 7.60 (10.41) | 4.17 (8.16) | 3.62 (7.36) | 4.08 (8.04) |
Air trapping, % | 23.85 (20.08) | 24.81 (20.62) | 23.95 (20.14) | 16.45 (17.64) | 14.67 (16.95) | 16.17 (17.54) |
Clinical characteristics | Ā | Ā | ||||
SGRQ, total score | 25.8 (22.2) | 26.39 (22.90) | 25.85 (22.29) | 29.84 (23.38) | 28.27 (22.89) | 29.59 (23.31) |
MMRCā>ā2, n (%) | 1447 (26.0) | 178 (27.2) | 1625 (26.1) | 725 (34.6) | 123 (30.5) | 848 (34.0) |
6-MWD, feet | 1400 (389) | 1422 (386) | 1402 (389) | 1243 (388) | 1274 (363) | 1249 (384) |
Comorbidities | Ā | Ā | ||||
Cong. Heart Failure, n (%) | 170 (3.1) | 23 (3.5) | 193 (3.1) | 74 (3.5) | 11 (2.7) | 85 (3.4) |
Coronary Art. Dis., n (%) | 496 (8.9) | 59 (9.0) | 555 (8.9) | 56 (2.7) | 13 (3.2) | 69 (2.8) |
Diabetes, n (%) | 680 (12.2) | 72 (11.0) | 752 (12.1) | 331 (15.8) | 67 (16.6) | 398 (15.9) |
Hypertension, n (%) | 2395 (43.0) | 261 (39.8) | 2656 (42.7) | 997 (47.6) | 181 (44.9) | 1178 (47.1) |
Hyperlipidemia, n (%) | 2589 (46.5) | 302 (46.0) | 2891 (46.4) | 583 (27.8) | 108 (26.8) | 691 (27.7) |
Asthma, n (%) | 933 (16.7) | 115 (17.5) | 1048 (16.8) | 514 (24.5) | 102 (25.3) | 616 (24.6) |