From: High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils
Parameter | Controls | All asthma | Asthma with mild IgE and eosinophilsd | Asthma with elevated IgE and eosinophilse | All asthma vs controls p value | Elevated vs mild allergic asthma p value |
---|---|---|---|---|---|---|
N | 26 | 29 | 12 | 17 | Ā | Ā |
Gender (M/F) | 9/17 | 13/16 | 6/6 | 7/10 | pā>ā0.4 | pā>ā0.6 |
Age (yr) | 37āĀ±ā11 | 31āĀ±ā11 | 31āĀ±ā9 | 31āĀ±ā12 | pā<ā0.05f | pā>ā0.9 |
Race (B/W/H/O)a | 12/7/4/3 | 15/5/7/2 | 8/1/2/1 | 7/4/5/1 | pā>ā0.9 | pā>ā0.7 |
Body mass index | 26āĀ±ā4 | 28āĀ±ā5 | 29āĀ±ā5 | 27āĀ±ā5 | pā<ā0.04 | pā>ā0.2 |
Asthma severity (mild/moderate/severe)b | ā | 15/10/4 | 7/3/2 | 8/7/2 | ā | pā>ā0.8 |
IgE (IU/ml) | 39āĀ±ā38 | 627āĀ±ā897 | 66āĀ±ā32 | 1023āĀ±ā1002 | pā<ā0.002 | pā<ā0.003 |
Absolute eosinophils (Ćā103/Ī¼l) | 0.2āĀ±ā0.1 | 0.5āĀ±ā0.4 | 0.2āĀ±ā0.1 | 0.8āĀ±ā0.3 | pā<ā10ā4 | pā<ā10ā4 |
Inhaled corticosteroids (on/not on) | ā | 9/20 | 3/9 | 6/11 | ā | pā>ā0.8 |
Pulmonary function parametersc | ||||||
Ā FVC | 112āĀ±ā12 | 104āĀ±ā16 | 103āĀ±ā18 | 104āĀ±ā15 | pā<ā0.03 | pā>ā0.9 |
Ā FEV1 | 109āĀ±ā11 | 87āĀ±ā13 | 89āĀ±ā12 | 85āĀ±ā14 | pā<ā10ā8 | pā>ā0.2 |
Ā % change FEV1 post-bronchodilator | 2.6āĀ±ā2.8 | 11.4āĀ±ā5.0 | 10.6āĀ±ā2.7 | 11.9āĀ±ā5.9 | pā<ā10ā4 | pā>ā0.5 |
Ā FEV1/FVC | 81āĀ±ā4 | 71āĀ±ā9 | 73āĀ±ā7 | 69āĀ±ā11 | pā<ā10ā5 | pā>ā0.2 |
Ā TLC | 103āĀ±ā16 | 103āĀ±ā18 | 99āĀ±ā18 | 105āĀ±ā17 | pā>ā0.9 | pā>ā0.3 |
Ā DLCO | 92āĀ±ā10 | 88āĀ±ā11 | 89āĀ±ā10 | 87āĀ±ā11 | pā>ā0.2 | pā>ā0.3 |