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Table 1. Demographics of the study population

From: High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils

Parameter

Controls

All asthma

Asthma with mild IgE and eosinophilsd

Asthma with elevated IgE and eosinophilse

All asthma vs controls

p value

Elevated vs mild allergic asthma

p value

N

26

29

12

17

Ā Ā 

Gender (M/F)

9/17

13/16

6/6

7/10

pā€‰>ā€‰0.4

pā€‰>ā€‰0.6

Age (yr)

37ā€‰Ā±ā€‰11

31ā€‰Ā±ā€‰11

31ā€‰Ā±ā€‰9

31ā€‰Ā±ā€‰12

pā€‰<ā€‰0.05f

pā€‰>ā€‰0.9

Race (B/W/H/O)a

12/7/4/3

15/5/7/2

8/1/2/1

7/4/5/1

pā€‰>ā€‰0.9

pā€‰>ā€‰0.7

Body mass index

26ā€‰Ā±ā€‰4

28ā€‰Ā±ā€‰5

29ā€‰Ā±ā€‰5

27ā€‰Ā±ā€‰5

pā€‰<ā€‰0.04

pā€‰>ā€‰0.2

Asthma severity (mild/moderate/severe)b

ā€“

15/10/4

7/3/2

8/7/2

ā€“

pā€‰>ā€‰0.8

IgE (IU/ml)

39ā€‰Ā±ā€‰38

627ā€‰Ā±ā€‰897

66ā€‰Ā±ā€‰32

1023ā€‰Ā±ā€‰1002

pā€‰<ā€‰0.002

pā€‰<ā€‰0.003

Absolute eosinophils (Ɨā€‰103/Ī¼l)

0.2ā€‰Ā±ā€‰0.1

0.5ā€‰Ā±ā€‰0.4

0.2ā€‰Ā±ā€‰0.1

0.8ā€‰Ā±ā€‰0.3

pā€‰<ā€‰10ā€“4

pā€‰<ā€‰10ā€“4

Inhaled corticosteroids (on/not on)

ā€“

9/20

3/9

6/11

ā€“

pā€‰>ā€‰0.8

Pulmonary function parametersc

Ā FVC

112ā€‰Ā±ā€‰12

104ā€‰Ā±ā€‰16

103ā€‰Ā±ā€‰18

104ā€‰Ā±ā€‰15

pā€‰<ā€‰0.03

pā€‰>ā€‰0.9

Ā FEV1

109ā€‰Ā±ā€‰11

87ā€‰Ā±ā€‰13

89ā€‰Ā±ā€‰12

85ā€‰Ā±ā€‰14

pā€‰<ā€‰10ā€“8

pā€‰>ā€‰0.2

Ā % change FEV1 post-bronchodilator

2.6ā€‰Ā±ā€‰2.8

11.4ā€‰Ā±ā€‰5.0

10.6ā€‰Ā±ā€‰2.7

11.9ā€‰Ā±ā€‰5.9

pā€‰<ā€‰10ā€“4

pā€‰>ā€‰0.5

Ā FEV1/FVC

81ā€‰Ā±ā€‰4

71ā€‰Ā±ā€‰9

73ā€‰Ā±ā€‰7

69ā€‰Ā±ā€‰11

pā€‰<ā€‰10ā€“5

pā€‰>ā€‰0.2

Ā TLC

103ā€‰Ā±ā€‰16

103ā€‰Ā±ā€‰18

99ā€‰Ā±ā€‰18

105ā€‰Ā±ā€‰17

pā€‰>ā€‰0.9

pā€‰>ā€‰0.3

Ā DLCO

92ā€‰Ā±ā€‰10

88ā€‰Ā±ā€‰11

89ā€‰Ā±ā€‰10

87ā€‰Ā±ā€‰11

pā€‰>ā€‰0.2

pā€‰>ā€‰0.3

  1. Data are presented as meanā€‰Ā±ā€‰standard deviation, p values of numeric parameters calculated using a 2-tailed Studentā€™s t-test with unequal variance, p value of categorical parameters calculated using a chi-square test
  2. aB: Black; W: White; H: Hispanic; O: Other
  3. bMild: mild intermittent and mild persistent; moderate: moderate persistent; severe: severe persistent
  4. cPulmonary function testing parameters are given as % of predicted value, with the exception of FEV1/FVC, which is reported as % observed; FVC forced vital capacity, FEV1 forced expiratory volume in 1Ā s, TLC total lung capacity, DLCO diffusing capacity
  5. d Mild IgE (ā‰¤165 IU/ml) and eosinophils (<ā€‰0.45ā€‰Ć—ā€‰103/Ī¼l)
  6. e Elevated IgE (>165 IU/ml) and eosinophils (ā‰„ā€‰0.45ā€‰Ć—ā€‰103/Ī¼l)
  7. f Threshold for significance: pĀ <Ā 0.05 (highlighted in bold)