Table 1 Characteristics of the study population at baseline
From: Dysregulation of iron homeostasis in airways associated with persistent preschool wheezing
Characteristic | Control, N = 56 | Resolution of wheezing, N = 36 | Persistence of wheezing, N = 48 | P value* | P value†|
|---|---|---|---|---|---|
Sex (% male) | 29 (51.8) | 24 (66.7) | 28 (58.3) | 0.36 | 0.44 |
Age (month), median (IQR) | 2.29 (1.2, 4.2) | 3.39 (1.8, 4.5) | 2.92 (1.6, 4.2) | 0.70 | 1.00 |
Preterm (%) | 4 (7.1) | 6 (16.7) | 8 (16.7) | 0.13 | 1.00 |
Cesarian section (%) | 20 (64.3) | 19 (52.8) | 23 (47.9) | 0.14 | 0.66 |
Breastfeeding time (month), median (IQR) | 8.0 (6.0, 12.0) | 9.5 (6.0, 12.0) | 6.0 (5.8, 10.0) | 0.14 | 0.008 |
Family history of asthma (%) | 5 (8.9) | 7 (19.4) | 16 (33.3) | 0.004 | 0.16 |
Allergic rhinitis (%) | 12 (21.4) | 19 (52.8) | 35 (72.9) |  < 0.001 | 0.057 |
History of eczema (%) | 22 (39.3) | 19 (52.8) | 29 (60.4) | 0.035 | 0.48 |
Allergy history (%) | 7 (12.5) | 9 (25.0) | 10 (20.8) | 0.080 | 0.65 |
Prenatal smoking (%) | 11 (20) | 17 (47) | 21 (44.8) | 0.004 | 0.75 |
Pet ownership (%) | 4 (7.1) | 1 (2.8) | 4 (8.3) | 0.73 | 0.39 |
First wheezing episode age (month), median (IQR) |  −  | 10 (4.0, 24.0) | 8 (4.5, 13.5) |  −  | 0.67 |
Past wheezing episodes ≥ 5 (%) |  −  | 16 (44%) | 34 (71%) |  −  | 0.015 |
Phenotype of wheezing (% EVW) |  −  | 23 (63.9) | 29 (60.4) |  −  | 0.75 |
Positive mAPI (%) |  −  | 7 (19.4) | 26 (54.2) |  −  | 0.001 |
mAPI major criteria (%) | Â | Â | Â | Â | Â |
 Parental asthma | 2 (3.6) | 5 (13.9) | 5 (10.4) | 0.13 | 0.74 |
 Atopic dermatitis | 1 (1.8) | 4 (11.1) | 4 (8.3) | 0.15 | 0.72 |
 Aeroallergens allergy |  −  | 11 (30.6) | 26 (54.2) |  −  | 0.031 |
mAPI minor criteria (%) | Â | Â | Â | Â | Â |
 Wheezing without colds |  −  | 13 (36.1) | 19 (39.6) |  −  | 0.75 |
 Food allergy |  −  | 11 (30.6) | 18 (37.5) |  −  | 0.51 |
 Eosinophilia (≥ 4%) | 4 (7.1) | 7 (19.4) | 15 (31.2) | 0.005 | 0.22 |