Skip to main content
Fig. 5 | Respiratory Research

Fig. 5

From: Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation

Fig. 5

DGK inhibition mitigates airway smooth muscle cell proliferation by inducing anti-mitogenic signaling involving PKA. The proposed mechanism demonstrates that enhanced accumulation of DAG levels by DGK inhibitor induces PGE2 secretion via a PKC-ERK1/2-COXII axis. Secreted PGE2 potentiates PKA-mediated anti-mitogenic signaling by activating Gs-coupled GPCRs

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us