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Table 3 Association of pre-diagnosis exposure to ozone pollution with the severity of SSc-associated ILD at diagnosis (extensive ILD): two-pollutant model

From: The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study

 

OR

p value

O3

 + NO2

1.24 (1.08–1.51)

0.007

 + PM10

1.16 (1.06–1.30)

0.002

 + PM2.5

1.19 (1.06–1.34)

0.003

  1. Logistic regression model adjusted for birth in Europe, tobacco smoking, anti-topoisomerase I antibodies positivity, usual interstitial pneumonia pattern, time between first non-Raynaud symptom and ILD diagnosis and year of ILD diagnosis
  2. ILD: interstitial lung disease; NO2: nitrogen dioxide; O3: ozone; PM10 and PM2.5: particles with a 50% cutoff aerodynamic diameter of 10 µm and 2.5 µm, respectively