Table 2 Clinical measurements of vitals during the follow-up after treatment (starting 0 min after) with MSCs (gray, n = 6) or with placebo (n = 6): oxygen saturation (SpO2, %), heart rate (HR, beats per minute, bpm), mean arterial pressure (MAP, mmHg), central venous pressure (CVP, mmHg); hemodynamic variables: mean pulmonary pressure (MPP, mmHg), pulmonary artery wedge pressure (Wedge, mmHg), cardiac index (CI, L/min/m2), systemic vascular resistance index (SVRI, dynes s/cm5 m2), pulmonary vascular resistance index (PVRI, dynes s/cm5 m2); blood gas parameters: pH, partial pressure of carbon dioxide (pCO2, mmHg), lactate (mmol/L), base excess (BE, mmol/L), mechanical ventilator settings with volume-controlled ventilation: minute volume (MV, L/min), peak inspiratory pressure (cmH2O), dynamic compliance (mL/cmH2O), ratio of partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2, mmHg)
0 min | 60 min | 120 min | 240 min | 360 min | 480 min | 600 min | End Point (EP) | |
|---|---|---|---|---|---|---|---|---|
Saturation, SpO2 (%) | 93.8 ± 1.2 | 94.3 ± 2.6 | 95 ± 2.8 | 95 ± 1.7 | 94 ± 1.9 | 95.7 ± 4.0 | 97 ± 1 | 95.2 ± 2.5 |
95.8 ± 3.1 | 94.5 ± 4.0 | 96.3 ± 2.7 | 95.4 ± 2.4 | 95.4 ± 4.2 | 96 ± 3.5 | 96.2 ± 5.8 | 96.7 ± 4.4 | |
HR (bpm) | 121.3 ± 8.9 | 124.7 ± 8.6 | 124.8 ± 13.2 | 117.6 ± 15.5 | 111 ± 11.4 | 108.7 ± 9.0 | 99 ± 7.9 | 105.2 ± 14.3 |
133.5 ± 42.6 | 145.3 ± 51.4 | 137.3 ± 48.2 | 132.2 ± 40.5 | 116 ± 20.0 | 110 ± 19.9 | 112 ± 19.7 | 109.7 ± 22.9 | |
MAP (mmHg) | 80.7 ± 20.1 | 77.7 ± 18.7 | 70.8 ± 16.6 | 74.4 ± 16.1 | 70.4 ± 16.4 | 68.7 ± 12.9 | 66.0 ± 18.2 | 57.2 ± 10.3 |
78.8 ± 29.2 | 80.3 ± 29.7 | 77.5 ± 26.8 | 92.0 ± 11.7 | 75.0 ± 8.2 | 75.4 ± 9.7 | 65.6 ± 8.4 | 57.8 ± 10.4 | |
CVP (mmHg) | 5.8 ± 3.0 | 4.8 ± 2.7 | 5.5 ± 2.5 | 7 ± 3.2 | 9.4 ± 4.7 | 7 ± 2.7 | 6.7 ± 4.7 | 10.2 ± 3.9 |
5.8 ± 4.1 | 6.7 ± 3.9 | 6.5 ± 2.8 | 8.4 ± 3.2 | 7.4 ± 2.6 | 8.6 ± 3.9 | 9 ± 4.2 | 9.8 ± 4.2 | |
MPP (mmHg) | 33.8 ± 10.9 | 28.3 ± 8.6 | 25.8 ± 8.2 | 27.8 ± 9.2 | 34 ± 7.5 | 25 ± 6.1 | 24.3 ± 2.1 | 28.7 ± 9.0 |
33.7 ± 7.5 | 34.3 ± 6.4 | 29.8 ± 6.8 | 27.2 ± 5.2 | 24.6 ± 8.8 | 22.4 ± 6.9 | 23 ± 6.4 | 23.7 ± 6.8 | |
Wedge (mmHg) | 10.0 ± 3.4 | 8.2 ± 1.8 | 8.3 ± 2.8 | 9.6 ± 4.3 | 15.8 ± 7.2 | 9.7 ± 2.3 | 10.3 ± 1.5 | 13.5 ± 6.9 |
9.0 ± 3.3 | 9.2 ± 2.6 | 10.7 ± 2.9 | 11.6 ± 5.0 | 12.6 ± 10.0 | 11 ± 3.8 | 11.4 ± 4.3 | 11.5 ± 4.5 | |
CI (L/min m2) | 4.7 ± 1.0 | 4.6 ± 1.6 | 4.4 ± 1.5 | 4.7 ± 1.2 | 4.5 ± 0.9 | 4.6 ± 0.3 | 4.5 ± 0.2 | 4.0 ± 0.7 |
4.5 ± 1.0 | 5.0 ± 1 | 5.6 ± 1.9 | 4.7 ± 0.7 | 4.5 ± 1.0 | 4.5 ± 1.5 | 5.0 ± 1.8 | 5.3 ± 2.1 | |
SVRI (dynes s/cm5 m2) | 1594.5 ± 875.3 | 1425.7 ± 769.2 | 1440.6 ± 685.8 | 1216.4 ± 434.4 | 1020.2 ± 333.5 | 1144.7 ± 214.3 | 1109.3 ± 297.0 | 886.2 ± 305.1 |
1244.2 ± 290.6 | 1138.8 ± 412.5 | 1231.5 ± 636.2 | 1470.2 ± 195.0 | 1249.4 ± 289.8 | 1275.6 ± 358.4 | 971.6 ± 309.1 | 865 ± 432.7 | |
PVRI (dynes s/cm5 m2) | 446.5 ± 333.98 | 413.5 ± 263.3 | 440.6 ± 224.8 | 345.2 ± 161.9 | 309.4 ± 85.5 | 292.3 ± 109.9 | 272 ± 60.3 | 299.3 ± 106.6 |
433.2 ± 195.6 | 398.3 ± 148.4 | 354.7 ± 197.9 | 295.8 ± 145.7 | 241 ± 152.3 | 269 ± 151.6 | 255.4 ± 156.0 | 245 ± 138.7 | |
pH | 7.30 ± 0.05 | 7.34 ± 0.08 | 7.34 ± 0.07 | 7.34 ± 0.06 | 7.34 ± 0.04 | 7.35 ± 0.07 | 7.36 ± 0.09 | 7.30 ± 0.09 |
7.29 ± 0.03 | 7.27 ± 0.07 | 7.30 ± 0.04 | 7.33 ± 0.03 | 7.31 ± 0.08 | 7.34 ± 0.03 | 7.34 ± 0.03 | 7.31 ± 0.09 | |
PaCO2 (mmHg) | 53.7 ± 5.7 | 49.7 ± 5.3 | 47.5 ± 5.7 | 46.2 ± 6.3 | 46.7 ± 5.5 | 42.9 ± 2.9 | 40.4 ± 2.6 | 46.1 ± 6.3 |
49.1 ± 2.1 | 51.4 ± 9.2 | 47.3 ± 3.1 | 44.7 ± 4.9 | 44.4 ± 6.3 | 42.5 ± 4.1 | 42.7 ± 3.7 | 43.1 ± 4.5 | |
Lactate (mmol/L) | 2.37 ± 0.53 | 2.93 ± 0.96 | 3.4 ± 0.99 | 3.4 ± 2.05 | 3.12 ± 1.89 | 2.17 ± 1.39 | 2.33 ± 1.64 | 3.22 ± 1.78 |
2.9 ± 0.81 | 4.27 ± 1.91 | 5.03 ± 3.57 | 2.84 ± 2.32 | 1.9 ± 1.5 | 2.9 ± 1.57 | 2.96 ± 1.48 | 4.53 ± 4.57 | |
Base excess (mmol/L) | − 0.87 ± 4.25 | 0.08 ± 4.02 | − 1.38 ± 3.93 | − 1.66 ± 4.59 | − 1.76 ± 3.73 | − 1.77 ± 4.03 | − 2 ± 4.5 | − 3.68 ± 3.25 |
− 2.87 ± 1.45 | − 3.38 ± 2.09 | − 3.37 ± 2.51 | − 3.02 ± 0.33 | − 3.82 ± 2.84 | − 2.64 ± 2.18 | − 2.66 ± 2.24 | − 4.25 ± 4.06 | |
MV (L/min) | 6.07 ± 1.32 | 6.87 ± 1.37 | 7.63 ± 1.31 | 7.78 ± 0.75 | 7.88 ± 0.87 | 8.37 ± 1.72 | 8.7 ± 1.2 | 7.92 ± 1.32 |
6.58 ± 0.34 | 6.48 ± 3.01 | 7.73 ± 1.29 | 7.62 ± 0.92 | 7.94 ± 0.86 | 8.12 ± 0.52 | 8.34 ± 0.77 | 8.47 ± 0.78 | |
Peak inspiratory pressure (cmH2O) | 24.3 ± 3.18 | 25.23 ± 1.91 | 25.42 ± 1.69 | 24.02 ± 1.41 | 24.8 ± 2.59 | 23.33 ± 1.15 | 25.33 ± 3.21 | 27.73 ± 1.88 |
24.17 ± 2.79 | 25 ± 3.29 | 24 ± 4.05 | 23.4 ± 2.3 | 22.6 ± 1.14 | 23.4 ± 2.07 | 23.2 ± 2.28 | 24.17 ± 3.76 | |
Dynamic compliance (mL/cmH2O) | 14.72 ± 5.89 | 13.8 ± 5.11 | 13.73 ± 4.44 | 15.71 ± 3.02 | 15.4 ± 3.36 | 16.67 ± 2.08 | 15.33 ± 3.21 | 12.76 ± 4.13 |
15 ± 2.53 | 15 ± 2.97 | 15.83 ± 3.06 | 15.8 ± 2.39 | 16.4 ± 1.52 | 16 ± 1.87 | 16.2 ± 1.92 | 15.33 ± 2.73 | |
PaO2/FiO2 (mmHg) | 180.86 ± 77.49 | 156.36 ± 60.22 | 171.72 ± 80.26 | 172.97 ± 63.2 | 152.95 ± 95.6 | 195.63 ± 88.19 | 243.15 ± 75.81 | 203.83 ± 120.39 |
232.25 ± 54.39 | 208.67 ± 70.92 | 209.17 ± 66.08 | 214.15 ± 59.88 | 219.15 ± 70.57 | 242.62 ± 90.55 | 250.51 ± 66.1 | 237.34 ± 79.87 |