Table 1 Clinical measurements of vitals during establishment of LPS-induced ARDS for treated subjects (gray, n = 6) and placebo (n = 6): oxygen saturation (SpO2, %), heart rate (HR, beats per minute, bpm), mean arterial pressure (MAP, mmHg), central venous pressure (CVP, mmHg); hemodynamic variables: mean pulmonary pressure (MPP, mmHg), pulmonary artery wedge pressure (Wedge, mmHg), cardiac index (CI, L/min), systemic vascular resistance index (SVRI, dynes s/cm5 m2), pulmonary vascular resistance index (PVRI, dynes s/cm5 m2); blood gas parameters: pH, partial pressure of carbon dioxide (pCO2, mmHg), lactate (mmol/L), base excess (BE, mmol/L), mechanical ventilator settings with volume-controlled ventilation: minute volume (MV, L), peak inspiratory pressure (cmH2O), dynamic compliance (mL/cmH2O), ratio of partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2, mmHg)
Baseline | 60 min | 120 min | Confirmed ARDS | |
|---|---|---|---|---|
Saturation, SpO2 (%) | 97.8 ± 1.6 | 96.3 ± 2.9 | 97.3 ± 0.6 | 96.5 ± 0.8 |
99.2 ± 0.8 | 99.2 ± 1.2 | 93 ± 11.8 | 95.8 ± 5.5 | |
HR (bpm) | 80.3 ± 17.0 | 115.5 ± 21.0 | 112.0 ± 28.5 | 121.2 ± 16.8 |
105.0 ± 23.8 | 93.3 ± 14.7 | 112.8 ± 20.1 | 112.3 ± 16.6 | |
MAP (mmHg) | 101.5 ± 18.6 | 112. ± 23.1 | 85 ± 24.1 | 96 ± 34.7 |
105.2 ± 10.5 | 102 ± 12.6 | 75 ± 18.1 | 83.8 ± 33.4 | |
CVP (mmHg) | 5.7 ± 3.1 | 5.5 ± 3.3 | 4 ± 2.7 | 4.8 ± 3.1 |
3.8 ± 1.6 | 6.5 ± 2.8 | 4.2 ± 1.92 | 5.5 ± 4.1 | |
MPP (mmHg) | 19.8 ± 2.9 | 35.2 ± 10.9 | 35.3 ± 15.4 | 30.2 ± 13.4 |
19.5 ± 6.8 | 25.2 ± 7.7 | 24.6 ± 5.6 | 32.7 ± 8.1 | |
Wedge (mmHg) | 11 ± 2 | 10.7 ± 2.7 | 9 ± 2.7 | 9.5 ± 2.1 |
9.5 ± 2.4 | 9.17 ± 2.99 | 8 ± 2 | 10 ± 3.41 | |
CI (L/min/m2) | 3.5 ± 1.0 | 3.9 ± 1.2 | 4.6 ± 1.0 | 4.3 ± 1.1 |
4.1 ± 1.7 | 4.4 ± 1 | 5.1 ± 1.9 | 4.6 ± 1.9 | |
SVRI (dynes s/cm5 m2) | 2384.8 ± 929.1 | 2309.7 ± 1103 | 2068.3 ± 1165.5 | 1752.7 ± 1211.6 |
2362.8 ± 1255.3 | 1834.8 ± 479.7 | 1269.4 ± 468.7 | 1551 ± 543.5 | |
PVRI (dynes s/cm5 m2) | 235.5 ± 85.4 | 620.3 ± 492.1 | 447 ± 194.0 | 497.2 ± 540.6 |
262.2 ± 90.2 | 306.2 ± 69.2 | 289 ± 99.4 | 462.7 ± 209.0 | |
pH | 7.46 ± 0.07 | 7.39 ± 0.07 | 7.36 ± 0.05 | 7.30 ± 0.02 |
7.47 ± 0.05 | 7.42 ± 0.04 | 7.36 ± 0.03 | 7.32 ± 0.03 | |
PaCO2 (mmHg) | 44.2 ± 8.7 | 49.4 ± 8.2 | 49.3 ± 5.3 | 51.6 ± 5.5 |
40.6 ± 5.9 | 43.7 ± 2.8 | 45.8 ± 1.9 | 47.5 ± 1.5 | |
Lactate (mmol/L) | 0.85 ± 0.21 | 1.18 ± 0.24 | 2.23 ± 0.6 | 2.25 ± 0.87 |
1 ± 0.38 | 1.2 ± 0.35 | 1.83 ± 0.32 | 2.48 ± 0.79 | |
BE (mmol/L) | 4.98 ± 2.48 | 3 ± 2.89 | 0.68 ± 3 | -1.17 ± 2.36 |
5.85 ± 1.12 | 3.6 ± 2.05 | 0.63 ± 1.55 | -1.53 ± 1.16 | |
MV (L) | 5.57 ± 0.61 | 5.68 ± 0.79 | 6.17 ± 1.61 | 5.93 ± 1.34 |
5.48 ± 0.43 | 5.57 ± 0.58 | 6.12 ± 0.55 | 6.33 ± 0.58 | |
Peak inspiratory pressure (cmH2O) | 16.4 ± 1.4 | 19.2 ± 2.45 | 20 ± 1.73 | 20.63 ± 2.08 |
18.17 ± 1.94 | 20.33 ± 2.42 | 21.4 ± 2.7 | 23.5 ± 1.76 | |
Dynamic compliance (mL/cmH2O) | 22.09 ± 8.07 | 17.49 ± 4.81 | 21.67 ± 4.16 | 16.51 ± 4.6 |
21.83 ± 4.07 | 19.17 ± 3.25 | 18.2 ± 2.86 | 15.67 ± 2.07 | |
PaO2/FiO2 (mmHg) | 480.25 ± 94.33 | 374 ± 82.54 | 281.97 ± 92.69 | 227.08 ± 52.82 |
514.36 ± 56.50 | 469.75 ± 46.78 | 340.5 ± 59.89 | 267.25 ± 29.17 |