Fig. 4

Monitoring of haemostasis by rotational thromboelastometry (ROTEM). Comparison of extrinsic (EXTEM) and intrinsic (INTEM) clotting parameters, and heparin modifications (HEPTEM) throughout the experiment. Samples were analysed before administration of lipopolysaccharide, after confirmed ARDS and in the early, mid, and lates phases of the monitoring following MSC or placebo administration, respectively. a Clotting time in seconds and b Maximum clot firmness in mm are shown for the treated group (green circles) and the placebo group (black squares). Multiple two-sided Mann–Whitney tests were used to compare the groups when data were not normally distributed. Mixed-effects analysis with Šídák’s multiple comparisons test was used to compare timepoints within each group. *p < 0.05 for comparisons within the treated group, ^#p < 0.05 for comparisons within the placebo group. Data are presented as mean ± standard deviation unless otherwise stated. Analyses conducted on treated group (n = 6) and placebo group (n = 6)