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Fig. 3 | Respiratory Research

Fig. 3

From: HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo

Fig. 3

HMGB1 stimulates PASMC proliferation and migration through PERK/ATF4/SIAH2/HIPK2 pathway. PASMCs were transferred with PERK siRNA, ATF4 siRNA, SIAH2 siRNA or NC siRNA for 24 h, then incubated with 100 ng/ml HMGB1 for 24 h. Cell proliferation was detected by EdU incorporation assay (a) and cell migration was measured by transwell assay (b). *P < 0.05

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Respiratory Research

ISSN: 1465-993X

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