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Fig. 2 | Respiratory Research

Fig. 2

From: HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo

Fig. 2

ER stress mediates HMGB1-induced SIAH2 upregulation and HIPK2 downregulation. The silencing effects of PERK (a), ATF4 (c) and SIAH2 (e) were evaluated by western blotting after specific siRNA or nontargeting siRNA transfection in cells for 48 h, respectively. b, d, f Specific siRNA or nontargeting siRNA was transfected into cells for 24 h, then cells were exposed to 100 ng/ml HMGB1for 24 h. ATF4, SIAH2 and HIPK2 protein levels were measured using western blotting. For original blot images, see Additional file 1. *P < 0.05

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Respiratory Research

ISSN: 1465-993X

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