Fig. 4

CC011 mice exhibit a stronger Th2-bias to HDM allergen than BALB/cJ mice. A Plasma total IgE from BALB/cJ and CC011 mice exposed to PBS or HDM for 5 weeks. n = 2–4/strain for PBS group (white-filled), n = 3–7/strain for HDM group (color-filled). Significance of t-tests for treatment effects within strain denoted by * for P < 0.05; significance of treatment-matched strain effects denoted as # for P < 0.05. B HDM-specific plasma IgE in BALB/cJ and CC011 mice exposed to HDM for 5 weeks. n = 3–7/strain. Significance of t-tests for treatment effects within strain denoted by * for P < 0.05. C Cytokine secretion following PBS or HDM stimulation in cultured mediastinal lymph nodes from BALB/cJ and CC011 mice exposed to HDM in 2-week model. n = 8/strain for PBS stimulated (white-filled) and n = 12–13/strain for HDM (color-filled) stimulated cultures. Significance of t-tests for treatment effects within strain denoted by * for P < 0.05; significance of t-tests for strain effects between HDM-exposed BALB/cJ and CC011 mice denoted by ^# for P < 0.05