Fig. 3
From: Collaborative cross strain CC011/UncJ as a novel mouse model of T2-high, severe asthma
CC011 mice chronically exposed to HDM exhibit histological features of severe asthma. A Representative cross-sections of large airways from CC011 control mice exposed to PBS for 5 weeks (top row) or collected immediately upon death from mice that succumbed to repeated HDM-exposure (bottom row). Large airway stained (from left to right) with H&E, Alcian Blue-Periodic Acid-Schiff (AB-PAS), Mason’s Trichrome (MT), and α-SMA by immunohistochemistry. Scale bars = 50 μM. B–D Additional abnormalities in HDM mouse shown in A with H&E staining. B H&E of whole lung cross-section. Scale bar = 500 μM. C Higher magnification image of airway with arrowheads pointing to extracellular crystals. Scale bars = 50 μM. D Higher magnification image with arrowheads indicating submucosal mast cells. Scale bar = 10 μM