Fig. 1
From: Collaborative cross strain CC011/UncJ as a novel mouse model of T2-high, severe asthma
CC011 mice exhibit extreme eosinophilic airway inflammation and fatalities due to chronic allergen exposure. A Chronic intranasal allergen exposure model. HDM or PBS delivered to mice intranasally (3 days/week for 5 weeks (arrows)). Mice were sacrificed 72 h after final exposure (gray X). B BAL differential cell type percentages in PBS and HDM-exposed BALB/cJ and CC011 mice (n = 2/strain PBS, 3–4/strain HDM). Significance of cell-type matched t-tests between BALB/cJ and CC011 mice denoted as * for P < 0.01. C Survival curve comparing HDM-exposed BALB/cJ vs. CC011 mice (n = 20–23/strain)