Table 1 Demographic data for Acute Lung Injury Registry cohort
Variable | Class 1 ARDS (N = 50) | Class 2 ARDS (N = 50) | Airway controls (N = 50) | P-value Class 1 vs. Class 2 | P-value Class 1 vs. Controls | P-value Class 2 vs. Controls |
|---|---|---|---|---|---|---|
Age, median [IQR], years | 56.0 [45.5, 64.4] | 56.5 [40.8, 65.5] | 54.0 [43.7, 63.3] | 0.83 | 0.74 | 0.76 |
Males, N (%) | 28 (56.0) | 25 (50.0) | 28 (56.0) | 0.69 |  > 0.99 | 0.69 |
BMI, median [IQR] | 33.5 [28.3, 37.7] | 28.6 [24.8, 32.2] | 26.7 [23.9, 29.6] | 0.0035 | 0.0005 | 0.25 |
Caucasian, N (%) | 48 (96.0) | 47 (94.0) | 46 (92.0) |  > 0.99 | 0.68 |  > 0.99 |
Non-Hispanic, N (%) | 49 (98.0) | 50 (100.0) | 50 (100.0) |  > 0.99 |  > 0.99 |  > 0.99 |
Time from intubation to sample collection, median [IQR], days | 1.5 [1, 3] | 1 [1, 2] | 1 [1, 2] | 0.29 | 0.0045 | 0.025 |
History of chronic disease | ||||||
 Diabetes, N (%) | 15 (30.0) | 16 (32.0) | 14 (28.0) |  > 0.99 |  > 0.99 | 0.83 |
 COPD, N (%) | 7 (14.0) | 11 (22.0) | 6 (12.0) | 0.44 |  > 0.99 | 0.29 |
 Congestive heart failure, N (%) | 4 (8.0) | 3 (6.0) | 3 (6.0) |  > 0.99 |  > 0.99 |  > 0.99 |
 Chronic lung disease, N (%) | 6 (12.0) | 5 (10.0) | 8 (16.0) |  > 0.99 | 0.77 | 0.55 |
 Chronic renal failure, N (%) | 4 (8.0) | 11 (22.0) | 6 (12.0) | 0.09 | 0.74 | 0.29 |
 Immunosuppression, N (%) | 7 (14.0) | 14 (28.0) | 10 (20.0) | 0.14 | 0.60 | 0.48 |
 Alcohol Use, N (%) | 4 (8.0) | 7 (14.0) | 13 (26.0) | 0.53 | 0.031 | 0.21 |
Risk factors for ARDS | ||||||
 Pneumonia, N (%) | 34 (68.0) | 31 (62.0) | 0 (0.0) | 0.68 | < 0.001 | < 0.001 |
 Sepsis, N (%) | 14 (28.0) | 13 (26.0) | 0 (0.0) |  > 0.99 | < 0.001 | < 0.001 |
 Pancreatitis, N (%) | 2 (4.0) | 2 (4.0) | 0 (0.0) |  > 0.99 | 0.50 | 0.50 |
 Aspiration, N (%) | 5 (10.0) | 12 (24.0) | 0 (0.0) | 0.11 | 0.056 | < 0.001 |
 LIPS score, median [IQR] | 6.5 [4.5, 8.5] | 7.3 [4.8, 9.8] | 3 (1.0, 5.0) | 0.016 | < 0.0001 | < 0.0001 |
Severity of illness | ||||||
 SOFA score, median [IQR] | 7 [5, 9] | 9 [7, 10] | 5 [4, 7] | 0.0138 | 0.0003 | < 0.0001 |
 Worst PaO2:FiO2 ratio, median [IQR], mm Hg | 110.5 [84.0, 175.0] | 137.5 [93.0, 202.0] | 205.0 [164.0, 273.0] | 0.14 | < 0.0001 | 0.0001 |