Treatment of obstructive sleep apnea in high risk pregnancy: a multicenter randomized controlled trial

Respiratory Research

Table 6 Explorative comparison of treatment effects between usual-care, CPAP non-adherent (average-CPAP use < 4 h/night), and CPAP-adherent (average-CPAP use ≥ 4 h/night) subgroups

	Usual-care (n = 157)	CPAP non-adherent subgroup (n = 103)	CPAP-adherent subgroup (n = 50)	p value
Treatment effect
Overall mean blood pressure (SE) after randomization
Systolic blood pressure, mmHg	116.07 (0.92)	115.11 (1.16)	112.22 (1.64)
∆Overall difference^a	Reference	− 0.96 (− 3.87, 1.95)	− 3.85* (− 7.54, − 0.14)	0.041
∆Adjusted overall difference^b	Reference	− 0.83 (− 3.43, 1.77)	− 4.38* (− 7.68, − 1.08)	0.009
Diastolic blood pressure, mmHg	72.50 (0.61)	70.89 (0.77)	69.28 (1.08)
∆Overall difference^a	Reference	− 1.61 (− 3.53, 0.305)	− 3.23* (− 5.66, − 0.79)	0.009
∆Adjusted overall difference^b	Reference	− 1.48 (− 3.11, 0.16)	− 3.54* (− 5.62, − 1.46)	0.009
Mean arterial blood pressure, mmHg	87.03 (0.68)	85.64 (0.86)	83.59 (1.21)
∆Overall difference^a	Reference	− 1.39 (− 3.54, 0.75)	− 3.44* (− 6.16, − 0.71)	0.013
∆Adjusted overall difference^b	Reference	− 1.26 (− 3.10, 0.59)	− 3.83* (− 6.17, − 1.49)	0.001

CPAP continuous positive airway pressure; SE standard error of mean
*Denotes statistical significance, p-value < 0.05 compared to usual-care subgroup
^aIntergroup difference is calculated as change in CPAP non-adherent and CPAP-adherent subgroups compared to that usual-care group using longitudinal data analysis with mixed-effect model after randomization presented as mean difference and 95%confidence interval (95%CI)
^bIntergroup difference is calculated as change in CPAP non-adherent and CPAP-adherent subgroups compared to that usual-care group using longitudinal data analysis with mixed-effect model after randomization presented as mean difference and 95%confidence interval (95%CI) adjusted with chronic hypertension status, and anti-hypertensive medication use, and gestational age

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