Treatment of obstructive sleep apnea in high risk pregnancy: a multicenter randomized controlled trial

Respiratory Research

Table 5 Secondary outcomes on preeclampsia, pregnancy-induced hypertension using the modified intention-to-treat analysis

Endpoints	CPAP group	Usual-care group	Risk difference, % (95%CI)^a	Number needed to treat (95%CI)^a	p value
Modified intention to treat analysis	(n = 153)	(n = 157)
Preeclampsia, no. (%)	20 (13.1)	35 (22.3)	− 9 (− 18, − 1)	11 (1, 21)	0.032
Severe preeclampsia^b	13 (8.5)	22 (14.0)	− 6 (− 14, 13)	–	0.122
Early-onset preeclampsia^c	4 (2.6)	4 (2.6)	0.1 (− 4, 3.5)	–	0.97
Late-onset preeclampsia^d	16 (10.5)	31 (19.8)	− 9 (− 17, − 1.4)	11 (2, 20)	0.021
Hypertensive disorders in pregnancy^e, no. (%)	21 (13.7)	39 (24.8)	− 11 (− 20, − 2)	9 (2, 16)	0.012

CPAP continuous positive airway pressure; 95%CI 95% confidence interval
^aBinary logistic regression analysis was used to calculate the risk difference and number needed to treat of preeclampsia and pregnancy induced hypertension between participants in CPAP versus usual-care groups
^bSevere preeclampsia was defined according to Report of the American College of Obstetricians and Gynecologists’ Task Force on hypertension in pregnancy [31, 32]
^cEarly-onset preeclampsia was defined as developing preeclampsia before 34 completed weeks’ gestation
^dLate-onset preeclampsia was defined as developing preeclampsia at or beyond 34 weeks’ gestation
^eHypertensive disorders in pregnancy comprised of preeclampsia and gestational hypertension

ISSN: 1465-993X