Fig. 3

Temporal changes of diastolic blood pressure during pregnancy in CPAP and usual-care (no CPAP) groups during 18–20, 24–28, and 32–34 weeks gestation compared to baseline (gestational age < 16 weeks) in the modified intention-to-treat and per-protocol analyses. Note The BP nadir-point occurred at 24–28 weeks in both CPAP and usual-care groups. Modified intention-to-treat analysis Intra-group changes: ∆₁ difference within groups compared to baseline; *Denotes p-value < 0.05—CPAP group (lower panel): 18–20 weeks vs baseline, p-value = 0.005; 24–28 weeks vs baseline, p-value = 0.002; 32–34 weeks vs baseline, p-value = 0.006. Usual-care group (upper panel): 18–20 weeks vs baseline, p-value = 0.199; 24–28 weeks vs baseline, p-value = 0.002; 32–34 weeks vs baseline, p-value = 0.987. Inter-group changes: ∆₂ difference between groups during each timepoints; ^†Denotes p-value < 0.05—CPAP vs usual-care groups: baseline, p-value = 0.677; 18–20 weeks, p-value = 0.092; 24–28 weeks, p-value = 0.643; 32–34 weeks, p-value = 0.004. Per-protocol analysis Intra-group changes: ∆₁ difference within groups compared to baseline; *Denotes p-value < 0.05—CPAP group (lower panel): 18–20 weeks vs baseline, p-value = 0.009; 24–28 weeks vs baseline, p-value = 0.002; 32–34 weeks vs baseline, p-value = 0.023. Usual-care group (upper panel): 18–20 weeks vs baseline, p-value = 0.066; 24–28 weeks vs baseline, p-value < 0.001; 32–34 weeks vs baseline, p-value = 0.793. Inter-group changes: ∆₂ difference between groups during each timepoints; ^†Denotes p-value < 0.05—CPAP vs usual-care groups: baseline, p-value = 0.670; 18–20 weeks, p-value = 0.064; 24–28 weeks, p-value = 0.247; 32–34 weeks, p-value = 0.012