Fig. 2

Temporal changes of systolic blood pressure during pregnancy in CPAP and usual-care (no CPAP) groups during 18–20, 24–28, and 32–34 weeks gestation compared to baseline (gestational age < 16 weeks) in the modified intention-to-treat and per-protocol analyses. Note The BP nadir-point occurred at 24–28 weeks in both CPAP and usual-care groups. Modified intention-to-treat analysis Intra-group changes: ∆₁ = difference within groups compared to baseline; *Denotes p-value < 0.05—CPAP group (lower panel): 18–20 weeks vs baseline, p-value = 0.181; 24–28 weeks vs baseline, p-value = 0.020; 32–34 weeks vs baseline, p-value = 0.093. Usual-care group (upper panel): 18–20 weeks vs baseline, p-value = 0.592; 24–28 weeks vs baseline, p-value = 0.108; 32–34 weeks vs baseline, p-value = 0.268. Inter-group changes: ∆₂ = difference between groups during each timepoints; ^†Denotes p-value < 0.05—CPAP vs usual-care groups: baseline, p-value = 0.545; 18–20 weeks, p-value = 0.417; 24–28 weeks, p-value = 0.936; 32–34 weeks, p-value = 0.068. Per-protocol analysis Intra-group changes: ∆₁ difference within groups compared to baseline; *Denotes p-value < 0.05—CPAP group (lower panel): 18–20 weeks vs baseline, p-value = 0.037; 24–28 weeks vs baseline, p-value = 0.010; 32–34 weeks vs baseline, p-value = 0.036. Usual-care group (upper panel): 18–20 weeks vs baseline, p-value = 0.507; 24–28 weeks vs baseline, p-value = 0.014; 32–34 weeks vs baseline, p-value = 0.040. Inter-group changes: ∆₂ difference between groups during each timepoints; ^†Denotes p-value < 0.05—CPAP vs usual-care groups: baseline, p-value = 0.805; 18–20 weeks, p-value = 0.135; 24–28 weeks, p-value = 0.609; 32–34 weeks, p-value = 0.036