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Fig. 5 | Respiratory Research

Fig. 5

From: An ICD-Associated DAMP Gene signature predicts survival and immunotherapy response of patients with lung adenocarcinoma

Fig. 5

Functional analysis of DEGs based on the DAMP-related subtypes of LUAD patients. (A) The volcano plots displaying differentially expressed genes between Cluster1 and Cluster2 from TCGA dataset. (B) Chord plot depicting the relationship between genes and immune-related signaling pathways. The genes marked in red fonts refer to the most significant genes in immune-related signaling pathways. (C) Dots plot presents the GO signaling pathway enrichment analysis. The size of the dot represents gene count and the color of the dot represents – log10 (p. adjust-value). (D) GSEA enrichment plots of the Cluster1 and Cluster2 LUAD patients. (E) Violin plots of the protein expression of the three differential genes in normal and tumor samples in LUAD. P values were calculated using Fisher’s exact test or Wilcoxon rank sum test (*P < 0.05; **P < 0.01; ***P < 0.001)

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Respiratory Research

ISSN: 1465-993X

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