Fig. 2

Pan-cancer analysis of 28 DAMPs-related genes. (A) Heatmap of RNA expression alterations of the 28 DAMPs-related genes in 33 cancer types. RNA expression levels were calculated as log2 (average expression of the tumor). (B) The bubble plots showing the different protein level of 28 DAMPs-related genes in 7 types of cancer in CPTAC datasets. The color of the dots represents the protein level of genes that are calculated as the average protein expression of tumor to normal. Redder dots represent higher expression in cancer tissue. Greener dots represent higher expression in normal tissue. The size of the bubbles indicates the –log10 (p-Value). (C) The color of the dots represents the prognostic value of 28 genes in pan-cancer. Purple dots represent favorable genes. Yellow dots represent poor genes. The size of the bubbles indicates the – log10 (p-Value). (D) The bubble chart shows the correlation between CNV and mRNA expression level. Red indicates positive correlation, blue indicates negative correlation. The deeper color indicates spearman correlation coefficient. The bubble size indicates the – log10(p-Value). (E) Mutation frequency of the 28 DAMPs -related genes across 33 cancer types. P values were calculated using Spearman correlation test or Wilcoxon rank sum test (*P < 0.05; **P < 0.01; ***P < 0.001)