Table 5 Statistically significant downregulated reactome pathways after multi-omic analysis of PGVG + phytol lungs
From: Multi-omic assessment shows dysregulation of pulmonary and systemic immunity to e-cigarette exposure
Downregulated reactome | |
|---|---|
Name | P-value |
Activation of Chaperone Genes by ATF6-alpha | 0.00449 |
Signal Transduction | 0.00487 |
Formyl peptide receptors bind formyl peptides and many other ligands | 0.00538 |
Activation of C3 and C5 | 0.00628 |
Terminal pathway of complement | 0.00628 |
Activation of Genes by ATF4 | 0.00628 |
Activation of Chaperones by ATF6-alpha | 0.00717 |
Regulation of Gene Expression by Hypoxia-inducible Factor | 0.00806 |
Dissolution of Fibrin Clot | 0.00896 |
Peptide ligand-binding receptors | 0.0114 |
Apoptotic cleavage of cell adhesion proteins | 0.0116 |
PERK regulated gene expression | 0.0116 |
TRAF3-dependent IRF activation pathway | 0.0125 |
NICD traffics to nucleus | 0.0134 |
Beta-catenin phosphorylation cascade | 0.0134 |
Notch-HLH transcription pathway | 0.0134 |
Cellular responses to stress | 0.024 |
Cellular response to hypoxia | 0.024 |
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | 0.024 |
TRAF6 mediated IRF7 activation | 0.0249 |
Myogenesis | 0.0275 |
CDO in myogenesis | 0.0275 |
Adherens junctions interactions | 0.0275 |
Class A/1 (Rhodopsin-like receptors) | 0.0288 |
Complement cascade | 0.0293 |
Apoptotic cleavage of cellular proteins | 0.038 |
NOTCH1 Intracellular Domain Regulates Transcription | 0.0441 |
Constitutive Signaling by NOTCH1 HD + PEST Domain Mutants | 0.0458 |
GPCR ligand binding | 0.0489 |
Transcriptional Regulation of White Adipocyte Differentiation | 0.0493 |
Developmental Biology | 0.0493 |