Multi-omic assessment shows dysregulation of pulmonary and systemic immunity to e-cigarette exposure

Respiratory Research

Table 3 Statistically significant differentially expressed transcripts for the comparisons of Phytol vs FA and PGVG vs FA

	RNA	FC	log2(FC)	Nanostring Adj P
Phytol	Spp1	− 1.93	− 0.95	0.04
	Il22ra2	− 1.9	− 0.93	0.00436
	Cdkn1a	− 1.89	− 0.92	0.000725
	Eln	− 1.75	− 0.81	0.02
	Col5a3	− 1.69	− 0.75	0.02
	Trat1	− 1.61	− 0.69	0.04
	Hsp90aa1	− 1.6	− 0.68	0.00229
	Nod2	− 1.58	− 0.66	0.04
	Hsp90aa1	− 1.58	− 0.66	0.00168
	Hspb1	− 1.55	− 0.63	0.00495
	Fpr1	− 1.53	− 0.61	0.02
	Il18r1	− 1.53	− 0.61	0.00495
	Dynll1	− 1.53	− 0.61	0.02
	Timp1	1.51	0.59	0.0031
	Alpl	1.52	0.6	0.03
	Ccl17	1.52	0.6	0.00509
	Gli1	1.52	0.61	0.04
	Cd69	1.53	0.62	0.04
	Ptger4	1.56	0.64	0.00911
	Lif	1.62	0.7	0.01
	Alox12	1.68	0.75	0.00983
	Il2ra	1.71	0.77	0.04
	Ptgs2	1.82	0.86	0.00752
	Thbs1	1.85	0.89	0.00999
	Thbs1	1.87	0.9	0.00487
	Bdkrb1	1.86	0.9	0.0029
	Hif3a	1.9	0.92	0.03
	Ptgs2	1.94	0.96	0.00801
	Serpine1	1.95	0.97	0.000359
	Il1b	2.06	1.04	0.02
	Ctgf	2.06	1.04	0.00199
	Lcn2	2.25	1.17	0.02
	Lrg1	2.48	1.31	0.000658
	Egr1	2.68	1.42	0.01
	Ttn	7.51	2.91	0.05
	Muc5b	10.4	3.38	0.03
PGVG	Cd27	− 1.55	− 0.63	0.02
	Runx3	− 1.52	− 0.61	0.03
	Mapk11	− 1.41	− 0.49	0.02
	Dynll1	− 1.4	− 0.48	0.04
	Smad6	− 1.32	− 0.4	0.03
	Hsp90ab1	− 1.27	− 0.34	0.02
	Acaa2	1.26	0.33	0.04
	Serpine1	1.31	0.39	0.03
	Gzma	1.34	0.42	0.02
	Marco	1.35	0.44	0.03
	Ctgf	1.43	0.52	0.04
	Ptger4	1.47	0.55	0.02
	Ptger4	1.57	0.65	0.00863
	Hif3a	1.95	0.96	0.03
	Masp1	2.11	1.08	0.01
	Ltf	9.51	3.25	0.03
	Ttn	19.79	4.31	0.00996

Full list of all significantly differentially expressed mRNA transcripts between PGVG + phytol versus FA and also PGVG versus FA from Fig. 4

ISSN: 1465-993X