Table 2 Molecules selected as classifiers of the molecular subtypes of IPF in at least 3 iterations
Molecule | Number of iterations in which molecule was selected | Variable importance across iterations where selected Mean (standard deviation) |
|---|---|---|
GRB2 adapter protein | 4 | 5.96 (1.47) |
PKC-A | 4 | 4.92 (2.16) |
BCL2-like 1 protein | 3 | 3.93 (3.26) |
Sorting nexin 4 | 4 | 3.86 (1.67) |
DUS3 | 3 | 3.29 (1.34) |
IF4G2* | 5 | 3.28 (2.29) |
NDP kinase B* | 5 | 3.25 (2.54) |
GSK-3 alpha/beta | 4 | 3.20 (1.42) |
Cyclophilin F | 3 | 2.97 (0.84) |
DLRB1 | 3 | 2.96 (3.23) |
FER | 3 | 2.95 (2.06) |
UFC1* | 5 | 2.85 (0.91) |
Caspase-3 | 4 | 2.70 (1.46) |
14-3-3 | 3 | 2.66 (0.38) |
PKB beta | 3 | 2.41 (3.05) |
Sphingosine kinase 1 | 4 | 2.26 (2.06) |
PDE5A | 4 | 2.19 (1.51) |
HSP 60 | 3 | 2.14 (1.78) |
Cofilin-1 | 3 | 2.02 (1.13) |
SBDS | 4 | 1.96 (0.62) |
SMAD2 | 3 | 1.70 (0.73) |
ERK-1 | 4 | 1.69 (0.95) |
BARK1* | 5 | 1.63 (0.78) |
MAPK2 | 4 | 1.63 (0.99) |
CSK | 4 | 1.56 (1.01) |
Calcineurin | 4 | 1.50 (1.49) |
PKB a/b/g | 4 | 1.49 (0.72) |
RAC1 | 3 | 1.48 (0.73) |
IMB1 | 4 | 1.14 (0.69) |
Aflatoxin B1 aldehyde reductase | 3 | 1.02 (0.63) |
Cytochrome P450 3A4 | 3 | 0.97 (0.80) |
TEC | 4 | 0.91 (0.46) |
LYNB | 3 | 0.83 (0.42) |
XPNPEP1 | 3 | 0.73 (0.43) |
hsa-miR-744-5p* | 5 | 2.17 (1.33) |
hsa-miR-199a-5p | 3 | 1.94 (0.07) |
hsa-miR-126-5p | 3 | 1.61 (0.65) |
hsa-miR-107 | 3 | 1.46 (0.38) |
hsa-miR-3074-5p | 3 | 1.21 (0.15) |
hsa-miR-451a | 3 | 1.15 (0.30) |
hsa-miR-24-3p | 3 | 1.10 (0.11) |