Fig. 4

Random forest classification of subjects into molecular subtypes, based on the risk of experiencing the composite outcome of lung transplant or death (A), and the composite outcome of ≥ 10% absolute decline in FVC % predicted, lung transplant, or death (B) in each iteration of the cross-validation procedure. For all iterations, the HR was greater than 1, indicating a greater risk of these outcomes in subtype 1 compared to subtype 2. The associated tables show the HR, 95% CI, and p-values for each iteration in the training and validation datasets. HR: hazard ratio; CI: confidence interval