Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

Table 2 Top ASV-Gene, ASV-CpG and Gene-CpG pairs and their respective correlation values

	Correlation
(a) COPD effect
Top ASV-gene pairs
p Bacteroidetes g Prevotella – WDR72	− 0.797
p Bacteroidetes g Prevotella – AKR1C2	− 0.765
p Bacteroidetes g Prevotella – SETDB1	0.761
Top ASV-CpG pairs
p Bacteroidetes g Prevotella—CpG TIMP3;SYN3	0.7993
p Bacteroidetes g Prevotella—CpG UTP11L	0.791
p Bacteroidetes g Prevotella—CpG PHACTR2	− 0.760
Top Gene-CpG pairs
WDR72—CpG TIMP3;SYN3	− 0.799
WDR72—CpG UTP11L	− 0.784
AKR1C2—CpG UTP11L	− 0.775
(b) HIV effect
Top ASV-CpG pairs
p Actinobacteria g Scardovia—CpG FGF7	− 0.811
p Proteobacteria—CpG ABCF3	− 0.706
p Planctomycetes g Planctomyces—CpG ABCF3	− 0.706
(c) COPD*HIV Effect
Top ASV-gene pairs
p Bacteroidetes g Prevotella—FUZ	0.774
p Bacteroidetes g Prevotella—FASTKD3	− 0.747
p Bacteroidetes g Prevotella—ACVR1B	0.747
Top ASV-CpG pairs
p Bacteroidetes g Prevotella—CpG FUZ	− 0.785
p Bacteroidetes g Prevotella—CpG RP11-168P8.7	0.715
p Bacteroidetes g Prevotella—CpG PHLDB3	− 0.707
Top Gene-CpG pairs
WDR72—CpG FUZ	− 0.819
WDR72—CpG FUZ	− 0.800
AKR1C2—CpG FUZ	− 0.793

(a) COPD effect, (b) HIV effect, and (c) COPD*HIV effect. Correlation cutoff = 0.7

ISSN: 1465-993X