Fig. 3
From: Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis
Upregulation of signaling cascades and profibrotic markers in ASS1-deficient normal lung fibroblasts. A A protein network of inositol-responsive signaling pathways in ASS1-deficient lung fibroblasts identified by the MetaCore™ analytical suite. B A heatmap graph of the differentially expressed proteins involved in the inositol signaling pathway from the reverse-phase protein array (RPPA) profiles in control and ASS1-knockdown normal lung fibroblasts. C Immunoblotting analysis of inositol-responsive molecules and profibrotic markers in control and ASS1-knockdown normal lung fibroblasts. D Normalized expression levels of inositol-responsive molecules and profibrotic markers from (C). Data are represented as mean ± SE, n = 3