Fig. 5

The impact of H3K4me3 on biological process in LUAD. (A) Correlation analysis between H3K4me3-lncRNA score and different histone methylation enrichment scores. (B) The correlation matrix showed the correlation between histone trimethylation and tumor related biological process.(C) Comparison of the enrichment score of CD4⁺ T cell, CD8⁺ T cell, T cell activation via MHC pathway, and TGFβ between high and low H3K4me3 groups. (D) The proportion of different score groups of indicated molecular subtypes in the two H3K4me3 score patterns. (E) (F) (G) (H) Kaplan–Meier curves showing the predictive value of indicated molecular subtypes. E, survival curves based on CD4⁺ T cell activation and H3K4me3 level; F, survival curves based on CD8⁺ T cell activation and H3K4me3 level; G, survival curves based on T cell activation via MHC pathway score and H3K4me3 level; H, survival curves based on TGFβ activation and H3K4me3 level. (*p < 0.05; **p < 0.01; ***p < 0.001)