Fig. 1
From: Use of a pulmosphere model to evaluate drug antifibrotic responses in interstitial lung diseases
ILD lung pulmospheres are characterized by an invasive phenotype compared to controls. A Representative image of an invasive pulmosphere (ILD- top panel, control -bottom panel) depicting total area of invasion (purple) and inner core area (yellow). B Formula quantitating ZOI. C Scatter plot of control pulmospheres vs ILD pulmospheres depicting significantly higher invasiveness of the ILD pulmospheres n = 9 for control and 23 for ILD (Control Vs ILD, 54.63 ± 19.6 vs 516.2 ± 115.6, ***P value < 0.0001 estimated by Mann–Whitney test). D Simple linear regression analysis of ZOI% (invasiveness) with Δ %FVC (change in %FVC) showing positive correlation, P value < 0.001, R2 = 0.64, r = 0.80