Deciphering a cell death-associated signature for predicting prognosis and response to immunotherapy in lung squamous cell carcinoma

Table 1 The prognostic genes and their corresponding coefficients of four cell death signatures

Autophagy		Apoptosis		Necrosis		Cell death index*
Gene	Coefficient	Gene	Coefficient	Gene	Coefficient	Gene	Coefficient
*ATP6V0D1*	0.061855	*AKT2*	0.158365	*BAG4*	−0.13201	ATP6V0D1	0.002993
*ATP6V1B1*	0.122063	CASP4	0.124322	*CASP4*	0.056541	ATP6V1B1	0.101445
*DRAM2*	−0.07345	*CIDEC*	0.577543	CLDN18	0.069005	DRAM2	−0.05243
*GPSM1*	0.123344	DLC1	0.106105	EDA2R	0.002689	GPSM1	0.002896
HGF	0.031335	*HTRA2*	−0.34211	ILK	0.057365	LRRK2	0.059429
HTRA2	−0.33536	*PTGIS*	0.144802	*TNFRSF12A*	0.081038	MAPK3	0.052099
LAMTOR4	−0.0163	*STK24*	0.34035	*TNFRSF8*	0.246743	PINK1	0.052535
*LRRK2*	0.063269	TRADD	0.249061	*TRADD*	0.076235	RRAGB	−0.1565
*MAPK3*	0.153165					AKT2	0.045682
*PINK1*	0.094258					CIDEC	0.432594
PLK3	0.037796					HTRA2	−0.22073
PSAP	0.051802					PTGIS	0.096722
*RRAGB*	−0.24185					STK24	0.27515
TAB2	0.078248					BAG4	−0.10963
TRIM5	0.022462					CASP4	0.023206
						TNFRSF12A	0.041075
						TNFRSF8	0.150757
						TRADD	0.040029

*Cell death index consists of 8 autophagy-related genes (ATP6V0D1, ATP6V1B1, DRAM2, GPSM1, LRRK2, MAPK3, PINK1, and RRAGB), 5 apoptosis-related genes (AKT2, CIDEC, HTRA2, PTGIS, and STK24), and 5 necrosis-related genes (BAG4, CASP4, TNFRSF12A, TNFRSF8, and TRADD), which are highlighted in bold in the three pathways

ISSN: 1465-993X