Fig. 7
From: Morphologically intact airways in lung fibrosis have an abnormal proteome
The composition of fibrotic mucus. Laser capture microdissection coupled mass spectrometry was performed on the mucus plugs of 6 Usual Interstitial Pneumonia (UIP) patients. A A list of the most abundant secretome-associated proteins found in the fibrotic mucus shown as intensity Based Absolute Quantification (iBAQ). B Reactome pathway enrichment of UIP mucus represented as a dotplot. C Serial sections of UIP specimens stained for alcian blue/periodic acid Schiff’s (AB/PAS) or immunostained for MUC5B, MUC5AC, BPIFB1, PIGR, and TF (N = 4 UIP patients with 2 representative images shown). Scale bar represents 100 microns