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Fig. 1 | Respiratory Research

Fig. 1

From: Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p–HMGB1 axis

Fig. 1

Expression of circ-YES1 was increased in NSCLC cells and circ-YES1 knockdown inhibited cell proliferation and migration. A Expression of circ-YES1 in H1650, PC-9, A549, and HEAS-2B cells by qPCR. n = 3. Data are presented as means ± SD. ***P < 0.001 vs. HEAS-2B. B Genomic loci of the YES1 gene and circ-YES1. The black arrow indicates back-splicing. C Expression of circ-YES1 after transfection of cells with circ-YES1 siRNA (si-circ-YES1) or negative control siRNA (NC). n = 3. Data are presented as means ± SD. ***P < 0.001 vs. NC. D and E H1650 (D) and A549 (E) cell proliferation as assessed by CKK-8 assays. Data are presented as means ± SD. ***P < 0.001 vs. NC. n = 3. F and G H1650 and A549 cell proliferation as assessed by clone formation assays. n = 3. Data are presented as means ± SD. ***P < 0.001 vs. NC. H and I H1650 and A549 cell migration as assessed by Transwell assays. n = 3. Data are presented as means ± SD. ***P < 0.001 vs. NC

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Respiratory Research

ISSN: 1465-993X

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