Enhanced immune complex formation in the lungs of patients with dermatomyositis

Respiratory Research

Table 2 Evaluation of immunohistochemical staining

Expression intensity 0/1/2/3 (mean ± SD)	DM-ILD (n = 18)	IPF (n = 19)	P value
C3c	3/7/6/2 (1.389 ± 0.916)	17/2/0/0 (0.105 ± 0.315)	< 0.001
IgG	0/4/12/2 (1.889 ± 0.583)	4/10/5/0 (1.053 ± 0.705)	< 0.001
IgM	7/10/1/0 (0.667 ± 0.594)	17/2/0/0 (0.105 ± 0.315)	0.001
IgA	5/11/0/2 (0.944 ± 0.873)	4/9/6/0 (1.105 ± 0.737)	0.323
MDA5	0/1/15/2 (2.056 ± 0.416)	0/0/14/5 (2.263 ± 0.452)	0.161

Expression intensity score 0, negative staining; score 1, weakly positive; score 2, moderately positive; and score 3, strongly positive. Details are described in the “Methods” section
DM dermatomyositis; ILD interstitial lung disease; IPF idiopathic pulmonary fibrosis; MDA5 melanoma differentiation-associated gene 5

ISSN: 1465-993X