Fig. 5
From: Enhanced immune complex formation in the lungs of patients with dermatomyositis
Histopathological findings in the lungs of lung injury model mouse. A H&E staining of lung injury model mouse (transgenic mice treated with antisera) showing severe inflammatory cells infiltration with alveolar collapse. B H&E staining of control mouse (transgenic mice treated with rabbit sera). This shows only very mild inflammatory cells infiltration. C IHC staining with anti-human MDA5 mAb (clone H27) in lung injury model mouse showing extensive and strong expression in the alveolar epithelium. D IHC staining with anti-MDA5 mAb (clone H27) in control mouse showing very low expression in the alveolar epithelium