Fig. 2
From: Enhanced immune complex formation in the lungs of patients with dermatomyositis
Histopathological findings in the lungs of patients with DM-ILD and idiopathic pulmonary fibrosis (IPF). A Hematoxylin & eosin (H&E) staining of a patient with DM-ILD. This patient showed an exudative diffuse alveolar damage (DAD) pattern. B IHC staining with anti-MDA5 monoclonal antibody (mAb) (clone H27) in a patient with DM-ILD. MDA5 is extensively and strongly expressed in the alveolar epithelium. C H&E staining in a patient with IPF. This patient showed an exudative DAD pattern, as well as a usual interstitial pneumonia (UIP) pattern in the background. D IHC staining with anti-MDA5 mAb (clone H27) in a patient with IPF. There was strong MDA expression in the alveolar epithelium