Fig. 1
From: Enhanced immune complex formation in the lungs of patients with dermatomyositis
Comparative analysis of melanoma differentiation-associated gene 5 (MDA5) RNA in situ hybridization and immunohistochemical (IHC) staining using anti-human MDA5 monoclonal antibody (mAb) (clone H27) in a patient with dermatomyositis-related interstitial lung disease (DM-ILD). A Low-power view of IHC staining using the anti-MDA5 mAb clone H27. B Mid-power view. C High-power view. Damaged and foamy pneumocytes, alveolar macrophages, and fibrin were strongly positive. D High-power view of MDA5 RNA in situ hybridization. Damaged pneumocytes were positive (red arrows)