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Fig. 9 | Respiratory Research

Fig. 9

From: Classical monocyte-derived macrophages as therapeutic targets of umbilical cord mesenchymal stem cells: comparison of intratracheal and intravenous administration in a mouse model of pulmonary fibrosis

Fig. 9

Regulatory effect of MSCs on and ex vivo and in vitro Ly6c+/– macrophages activation. A Macrophage differentiation protocol of Ly6c+ or Ly6c– monocytes isolated from the BLM model. B mRNA levels of macrophage activation markers, fibrosis-related markers, and immune cell chemotaxis markers in Ly6c+ or Ly6c–MoMs. C Comparison of fibrosis-inducing ability of Ly6c+ or Ly6c– MoMs. n = 4–5 for each group, *indicates P < 0.05, **indicates P < 0.01, ***indicates P < 0.001, ****indicates P < 0.0001. All results are representative of at least three independent experiments. MSC mesenchymal stem cell, BLM bleomycin, MoM monocyte-derived macrophage

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Respiratory Research

ISSN: 1465-993X

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