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Fig. 8 | Respiratory Research

Fig. 8

From: Classical monocyte-derived macrophages as therapeutic targets of umbilical cord mesenchymal stem cells: comparison of intratracheal and intravenous administration in a mouse model of pulmonary fibrosis

Fig. 8

Regulatory effect of MSCs on in vivo and ex vivo Ly6c+/– macrophages activation. A, B Change of Ly6c+ and Ly6c− MoMs in lungs. C Changes in CD86 and CD206 marker expression populations in Ly6c+ MoMs in the lungs. D Ex vivo model to evaluate the regulation effect of Ly6c+ MoM on CD4+ T cell plasticity and the effect of MSC treatment on the regulation E Effect of MSC on the plasticity of naive CD4+ T cells co-cultured with Ly6c+ MoMs. n = 4–5 for each group, *indicates P < 0.05, **indicates P < 0.01, ***indicates P < 0.001, ****indicates P < 0.0001. All results are representative of at least three independent experiments. MSC mesenchymal stem cell, MoM monocyte-derived macrophage

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Respiratory Research

ISSN: 1465-993X

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